4 african antenatal and caribbean. For the purposes of this thesis sickle cell trait will be defined as someone with one copy of the mutant allele and sickle cell anemia as someone with two copies of the allele. Read about sickle cell anemia sickle cell disease a blood disease which shortens life expectancy is caused by an inherited abnormal hemoglobin. Sickle cell anemia is a genetic disease which results in vasoocclusive crisis of the blood. In this thesis the contribution of ams hbf and endothelial factors to the severity of sickle cell disease has been studied. Silly essays. The rest of this thesis is devoted to construct a multiscale model of the sickle red blood cell and use this model to quantify the biophysical characteristics of the sickle cell anemia. What is sickle cell disease español; the term sickle cell disease scd describes a group of inherited red blood cell disorders. Thesis statement sickle cell disease is an inherited disease that affects the red blood cells.
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